Manufacturer:

          AstraZeneca

Contents:

          Per 80/4.5 mcg dose Budesonide 80 mcg, formoterol fumarate dihydrate 4.5 mcg. Per 160/4.5 mcg dose Budesonide 160 mcg, formoterol fumarate dihydrate 4.5 mcg. Per 320/9 mcg dose Budesonide 320 mcg, formoterol fumarate dihydrate 9 mcg

Indications:

          Regular treatment of asthma using combination of inhaled corticosteroid & long-acting β2-agonist in patients not adequately controlled w/ inhaled corticosteroids & as needed inhaled short-acting β2-agonists or patients already adequately controlled on both inhaled corticosteroids & long-acting β2-agonists. Turbuhaler 160/4.5 mcg & 320/9 mcg Symptomatic treatment of patients w/ severe COPD (FEV1 <50% predicted normal) & history of repeated exacerbations who have significant symptoms despite regular therapy w/ long-acting bronchodilators.

Contraindications:

          Hypersensitivity to lactose.

Special Precautions:

          Turbuhaler 80/4.5 mcg/inhalation is not appropriate in patients w/ severe asthma. Not intended for the initial management of asthma. Prophylactic use eg before exercise. Dose should be tapered when the treatment is discontinued & should not be stopped abruptly. Exacerbation episodes, worsening or acutely deteriorating asthma; adrenal impairment due to previous systemic steroid therapy or high dose emergency corticosteroid therapy; prolonged treatment w/ high dose inhaled corticosteroids; thyrotoxicosis, phaeochromocytoma, DM, untreated hypokalaemia, hypertrophic obstructive cardiomyopathy, idiopathic subvalvular aortic stenosis, severe HTN, aneurysm or other severe CV disorders eg ischaemic heart disease, tachyarrhythmias or severe heart failure; prolonged QTc-interval; active or quiescent pulmonary TB; fungal & viral infections in the airways; unstable asthma w/ variable use of rescue bronchodilators, acute severe asthma; hepatic or renal impairment, severe liver cirrhosis. Pregnancy & lactation. Childn <12 yr & patients taking potent CYP3A4 inhibitors (maintenance & reliever therapy). Childn <6 yr.

Dosage:

          Turbuhaler 160/4.5 mcg & 80/4.5 mcg Asthma (maintenance & reliever therapy) Adult & adolescent ≥12 yr Maintenance dose: 2 inhalations/day, 1 inhalation in the morning & evening or as 2 inhalations either in the morning or evening. Additional inhalations may be taken as needed but not >6 inhalations/occasion. A total daily dose of up to 12 inhalations could be used for a limited period. Maintenance treatment w/ a separate rapid-acting bronchodilator as rescue Adult ≥18 yr 1-2 inhalations bd. Max: 4 inhalations bd. Adolescent 12-17 yr 1-2 inhalations bd. Turbuhaler 80/4.5 mcg Childn ≥6 yr 2 inhalations bd. Turbuhaler 320/9 mcgAsthma Adult ≥18 yr 1 inhalation bd. Max: 2 inhalations bd. Adolescent 12-17 yr 1 inhalation bd. COPD Adult Turbuhaler 320/9 mcg 1 inhalation bd. Turbuhaler 160/4.5 mcg 2 inhalations bd.

Class:

          Antiasthmatic & COPD Preparations

Presentation/Packing:

          Symbicort turbuhaler 160/4.5 mcg

Details:

          MyPhuocPharmacy – (08) 62581003