Manufacturer:

          Janssen-Cilag

Contents:

          Topiramate.

Indications:

          Monotherapy or adjunctive therapy in adults & childn w/ partial onset seizures & generalized seizures including tonic-clonic seizures. Adjunctive therapy in seizures associated w/ Lennox-Gastaut syndrome. Prophylaxis of migraine headache in adults.

Contraindications:

          Hypersensitivity to any of the ingredients

Special Precautions:

          Gradual w/drawal of therapy is recommended. Adequate hydration is required. Monitor for signs of suicidal ideation & behaviour. Patients at risk of predisposition to nephrolithiasis. Renal or hepatic impairment. May cause mood disturbances & depression. Acute myopia & secondary angle-closure glaucoma. Oligohydrosis & hyperthermia. Metabolic acidosis. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn <2 yr.

Dosage:

          Epilepsy Adjunctive therapy Adult & elderly Initially, 25-50 mg nightly for 1 wk. Subsequently at wkly or bi-wkly intervals, increase dose to 25-50 mg/day in 2 divided doses. Usual daily dose: 200-400 mg in 2 divided doses. Childn ≥2 yr 5-9 mg/kg/day in 2 divided doses. Titrate at 25 mg (or less based on range of 1-3 mg/kg/day) nightly for the 1st wk. Subsequently at 1- or 2-wk intervals w/ increments of 1-3 mg/kg/day in 2 divided doses. Max: 30 mg/kg/day. Monotherapy Adult Titrate at 25 mg nightly for 1 wk. Subsequently at 1- or 2-wk intervals, increase dose by increments of 25-50 mg/day in 2 divided doses. Initial target dose: 100 mg/day. Max: 500 mg daily. Childn ≥2 yr Initially, at 0.5-1 mg/kg nightly for the 1st wk, then increased at 1- or 2-wk interval by increment of 0.5-1 mg/kg/day in 2 divided doses. Initial target dose: 3-6 mg/kg/day. Migraine Titrate at 25 mg nightly for 1 wk. Increase by 25 mg/day increments at 1-wk intervals. Total daily dose: 100 mg/day in 2 divided doses.

Class:

          Anticonvulsants / Antimigraine Preparations

Presentation/Packing:

          Topamax 25 mg x 6 vỉ x 10 viên.
          Topamax 50 mg x 6 vỉ x 10 viên.

Details:

          MyPhuocPharmacy – (08) 62581003