NEXIUM

Manufacturer:

          AstraZeneca A.B

Contents:

          Esomeprazole

Indications:

          Listed in Dosage.

Contraindications:

          Hypersensitivity to substituted benzimidazoles. Childn <12 yr. Lactation. Tab Fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency.

Special Precautions:

          Exclude malignancy in the presence of significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis or melaena; & when gastric ulcer is suspected or present. Severe renal or hepatic impairment. Long-term treatment for >1 yr (tab). Pregnancy.

Dosage:

          Tab Adult & adolescent ≥12 yr Treatment of erosive reflux esophagitis 40 mg once daily for 4-8 wk. Long-term management of patients w/ healed esophagitis to prevent relapse 20 mg once daily. Symptomatic treatment of GERD 20 mg once daily in patients w/o esophagitis. Subsequently 20 mg once daily when needed. Adult Treatment & prevention of H. pylori-associated ulcers Nexium 20 mg w/ amoxicillin 1 g & clarithromycin 500 mg, all bd for 7 days. Healing of gastric ulcers associated w/ NSAID therapy 20 mg once daily for 4-8 wk. Prevention of gastric & duodenal ulcers associated w/ NSAID therapy in patients at risk 20 mg once daily. Prevention of rebleeding of gastric or duodenal ulcers 40 mg once daily for 4 wk after IV-induced prevention of rebleeding of peptic ulcers. Zollinger-Ellison syndrome 40 mg bd. Max: 80-160 mg. Doses >80 mg should be given bd. Inj 20 or 40 mg IV over a period of at least 3 min. Infusion: 20 or 40 mg IV infusion over a period of 10-30 min. 80 mg bolus dose via continuous IV over 30 min. 8 mg/hr dose via continuous IV over 71.5 hr. Patient unable to take oral medication 20-40 mg once daily. Reflux oesophagitis 40 mg once daily. Symptomatic treatment of reflux disease 20 mg once daily. Treatment & prevention of gastric & duodenal ulcers associated w/ NSAID therapy 20 mg once daily. Prevention of rebleeding of gastric & duodenal ulcers 80 mg bolus infusion over 30 min, followed by continuous IV infusion of 8 mg/hr for 3 days.

Class:

         Antacids, Antireflux Agents & Antiulcerants

Presentation/Packing:

       Nexium gastro-resistant tablet

         Nexium 20 mg x 14's

         Nexium 40 mg x 14's

Details:

           MyPhuocPharmacy – (08) 62581003

Esomeprazole

Tab Adult & adolescent ≥12 yr Treatment of erosive reflux esophagitis 40 mg once daily for 4-8 wk. Long-term management of patients w/ healed esophagitis to prevent relapse 20 mg once daily. Symptomatic treatment of GERD 20 mg once daily in patients w/o esophagitis. Subsequently 20 mg once daily when needed. Adult Treatment & prevention of H. pylori-associated ulcers Nexium 20 mg w/ amoxicillin 1 g & clarithromycin 500 mg, all bd for 7 days. Healing of gastric ulcers associated w/ NSAID therapy 20 mg once daily for 4-8 wk. Prevention of gastric & duodenal ulcers associated w/ NSAID therapy in patients at risk 20 mg once daily. Prevention of rebleeding of gastric or duodenal ulcers 40 mg once daily for 4 wk after IV-induced prevention of rebleeding of peptic ulcers. Zollinger-Ellison syndrome 40 mg bd. Max: 80-160 mg. Doses >80 mg should be given bd. Inj 20 or 40 mg IV over a period of at least 3 min. Infusion: 20 or 40 mg IV infusion over a period of 10-30 min. 80 mg bolus dose via continuous IV over 30 min. 8 mg/hr dose via continuous IV over 71.5 hr. Patient unable to take oral medication 20-40 mg once daily. Reflux oesophagitis 40 mg once daily. Symptomatic treatment of reflux disease 20 mg once daily. Treatment & prevention of gastric & duodenal ulcers associated w/ NSAID therapy 20 mg once daily. Prevention of rebleeding of gastric & duodenal ulcers 80 mg bolus infusion over 30 min, followed by continuous IV infusion of 8 mg/hr for 3 days.

Updating

Exclude malignancy in the presence of significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis or melaena; & when gastric ulcer is suspected or present. Severe renal or hepatic impairment. Long-term treatment for >1 yr (tab). Pregnancy.