Manufacturer:

          UCB

Contents:

          Levetiracetam.

Indications:

          Monotherapy in the treatment of partial onset seizures w/ or w/o secondary generalisation in patients ≥16 yr w/ newly diagnosed epilepsy. Adjunctive therapy in the treatment of partial onset seizures w/ or w/o secondary generalisation in adult & childn ≥4 yr w/ epilepsy; myoclonic seizures in adult & adolescent ≥12 yr w/ juvenile myoclonic epilepsy; primary generalised tonic-clonic seizures in adult & adolescent ≥12 yr w/ idiopathic generalised epilepsy.

Contraindications:

          Hypersensitivity to other pyrrolidone derivatives. Rare hereditary problems of fructose intolerance.

Special Precautions:

          Avoid abrupt w/drawal of therapy. Suicide, suicidal attempt & ideation & increase in seizure frequency may occur. Renal & severe hepatic impairment. Patients on a controlled sodium diet. May impair ability to drive or operate machinery. Pregnancy & lactation. Infants & childn <4 yr. Elderly.

Dosage:

          Monotherapy Adult & adolescent ≥16 yr Initially 250 mg bd, may be increased to 500 mg bd after 2 wk, can be further increased by 250 mg bd every 2 wk. Max: 1,500 mg bd. Add-on therapy Adult ≥18 yr & adolescent 12-17 yr, ≥50 kg Initially 500 mg bd, may be increased up to 1,500 mg bd. Dose changes can be made in 500 mg bd increments or decrements 2-4 wkly. Childn 4-11 yr & adolescent 12-17 yr, <50 kg Initially 10 mg/kg bd, may be increased up to 30 mg/kg bd. Dose changes should not exceed increments or decrements of 10 mg/kg bd every 2 wk. Childn ≥50 kg Adult dose. Adult w/ renal impairment CrCl >80 mL/min 500-1,500 mg; 50-79 mL/min 500-1,000 mg; 30-49 mL/min 250-750 mg; <30 mL/min 250-500 mg. Doses to be taken bd. End-stage renal disease patients undergoing dialysis 750-mg loading dose on 1st day, then 500-1,000 mg once daily. Followed by 250-500-mg supplemental dose after dialysis.

Class:

          Anticonvulsants

Presentation/Packing:

          Keppra 500 mg x 6 blisters x 10 film-coated tabs.

Details:

          nhathuoctot.com - 0937146168