Manufacturer:

          Servier

Contents:

          Perindopril arginine

Indications:

          Treatment of HTN, symptomatic heart failure. Reduction of risk of cardiac events in patients w/ history of MI &/or revascularisation.

Contraindications:

          History of angioedema associated w/ previous ACE inhibitor therapy; hereditary or idiopathic angioedema; rare hereditary problems of galactose intolerance, glucose-galactose malabsorption or Lapp lactase deficiency. Pregnancy.

Special Precautions:

          Unstable angina pectoris. Monitor symptomatic hypotension in patients who are vol-depleted or w/ symptomatic heart failure; w/ or w/o associated renal insufficiency; w/ more severe degrees of heart failure; ischaemic heart or cerebrovascular disease or CHF; mitral valve stenosis & left ventricular outflow obstruction eg aortic stenosis or hypertrophic cardiomyopathy; renal impairment (CrCl <60 mL/min); bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Patients w/ no apparent preexisting renal vascular disease; patients undergoing haemodialysis, history of angioedema/hypersensitivity, anaphylactoid reactions during LDL apheresis, anaphylactic reactions during desensitisation; hepatic failure; collagen vascular disease, immunosuppressant therapy; preexisting impaired renal function. Black patients. Discontinue treatment 1 day before surgery. Diabetic patients. May impair ability to drive or operate machinery. Lactation. Childn.

Dosage:

          HTN Initially 5 mg once daily in the morning, may be increased to 10 mg after 1 mth. Renovascular HTN, salt &/or vol depletion, cardiac decompensation or severe HTN Initially 2.5 mg, may be increased to 10 mg once daily after 1 mth. Elderly & hypertensive patients concurrently treated w/ diuretics Initially 2.5 mg once daily, may be increased to 5 mg after 1 mth then to 10 mg if necessary. Symptomatic heart failure Initially 2.5 mg once daily, may be increased to 5 mg after 2 wk. Stable coronary artery disease Initially 5 mg once daily for 2 wk, may be increased to 10 mg once daily. Elderly 2.5 mg once daily for 1 wk then 5 mg once daily the following wk, may be increased up to 10 mg once daily. CrCl ≥60 mL/min 5 mg/day, 30-60 mL/min 2.5 mg/day, 15-30 mL/min 2.5 mg every other day, <15 mL/min (haemodialysed patients) 2.5 mg on the day of dialysis (after dialysis).

Class:

          ACE Inhibitors/Direct Renin Inhibitors

Presentation/Packing:

          Coversyl film-coated tablet

Details:

          MyPhuocPharmacy – (08) 62581003