Manufacturer:

          GlaxoSmithKline

Contents:

          Per 625 mg tab Amoxicillin trihydrate 500 mg, clavulanate K 125 mg. Per 1 g tab Amoxicillin trihydrate 875 mg, clavulanate K 125 mg. Per 5 mL of 228 mg/5 mL susp Amoxicillin trihydrate 200 mg, clavulanate K 28.5 mg. Per 600 mg inj Amoxicillin Na 500 mg, clavulanate K 100 mg. Per 1.2 g inj Amoxicillin Na 1 g, clavulanate K 200 mg

Indications:

          Tab/Susp: Short-term treatment of infections eg upper & lower resp tract, GUT, skin & soft tissue, bone & joint infections, UTI, septic abortion, puerperal sepsis, intra-abdominal sepsis. Inj: In addition to the above, also indicated for prophylaxis against infection which may be associated w/ major surgical procedures eg GI, pelvic, head & neck, cardiac, renal, joint replacement & biliary tract.

Contraindications:

          Hypersensitivity to penicillins & cephalosporins, possible cross-sensitivity w/ other β-lactams. History of penicillin-associated jaundice/hepatic dysfunction.

Special Precautions:

          Suspected infectious mononucleosis. Prolonged use. Concomitant use of anticoagulants. Renal or hepatic impairment. Ensure adequate hydration & urinary output esp w/ parenteral therapy or high doses. Monitor prothrombin time or INR in patients maintained on acenocoumarol or warfarin. Pregnancy. 228 mg/5 mL susp: Phenylketonuria. Childn w/ GFR <30 mL/min. Infants w/ immature renal function.

Dosage:

          Tab Adult & childn >12 yr Mild to moderate infections 625 mg bd. Severe infections 1 g bd. Susp Usual recommended daily dosage: Mild to moderate infections (upper resp tract eg recurrent tonsillitis & lower resp tract infections, skin & soft tissue infections) 25/3.6 mg/kg/day. Childn 7-12 yr 10 mL of Augmentin 228 mg/5 mL susp bd, 2-6 yr 5 mL of Augmentin 228 mg/5 mL susp bd. Serious infections (upper resp tract infections eg otitis media, sinusitis & lower resp tract infections eg bronchopneumonia, UTI) 45/6.4 mg/kg/day. Childn 2-6 yr 10 mL of Augmentin 228 mg/5 mL susp bd, <2 yr dose according to body wt. Inj Treatment of infection Adult & childn >12 yr 1.2 g 8 hrly, increasing to 6 hrly in more serious infections. Childn 3 mth-12 yr 30 mg/kg 8 hrly, increasing to 6 hrly in more serious infections, 0-3 mth 30 mg/kg 12 hrly in premature infants & in full-term infants during the perinatal period, increasing to 8 hrly thereafter. Surgical prophylaxis Adult 1.2 g at the induction of anesth. Where there is a high risk of infection, 3-4 doses of 1.2 g may be needed in a 24-hr period. Continue regimen for several days if procedure has significantly increased risk of infection.

Class:

           Penicillin.

Presentation/Packing:

           Augmentin 1g x 2 blisters x 7 film-coated tablets
           Augmentin 625g x 2 blisters x 7 film-coated tablets
           Augmentin 500 mg x 12 sachets                                                
           Augmentin 250 mg x 12 sachets

Details:

          MyPhuocPharmacy – (08) 62581003

Per 625 mg tab Amoxicillin trihydrate 500 mg, clavulanate K 125 mg. Per 1 g tab Amoxicillin trihydrate 875 mg, clavulanate K 125 mg. Per 5 mL of 228 mg/5 mL susp Amoxicillin trihydrate 200 mg, clavulanate K 28.5 mg. Per 600 mg inj Amoxicillin Na 500 mg, clavulanate K 100 mg. Per 1.2 g inj Amoxicillin Na 1 g, clavulanate K 200 mg

Tab Adult & childn >12 yr Mild to moderate infections 625 mg bd. Severe infections 1 g bd. Susp Usual recommended daily dosage: Mild to moderate infections (upper resp tract eg recurrent tonsillitis & lower resp tract infections, skin & soft tissue infections) 25/3.6 mg/kg/day. Childn 7-12 yr 10 mL of Augmentin 228 mg/5 mL susp bd, 2-6 yr 5 mL of Augmentin 228 mg/5 mL susp bd. Serious infections (upper resp tract infections eg otitis media, sinusitis & lower resp tract infections eg bronchopneumonia, UTI) 45/6.4 mg/kg/day. Childn 2-6 yr 10 mL of Augmentin 228 mg/5 mL susp bd, <2 yr dose according to body wt. Inj Treatment of infection Adult & childn >12 yr 1.2 g 8 hrly, increasing to 6 hrly in more serious infections. Childn 3 mth-12 yr 30 mg/kg 8 hrly, increasing to 6 hrly in more serious infections, 0-3 mth 30 mg/kg 12 hrly in premature infants & in full-term infants during the perinatal period, increasing to 8 hrly thereafter. Surgical prophylaxis Adult 1.2 g at the induction of anesth. Where there is a high risk of infection, 3-4 doses of 1.2 g may be needed in a 24-hr period. Continue regimen for several days if procedure has significantly increased risk of infection.

Updating

Suspected infectious mononucleosis. Prolonged use. Concomitant use of anticoagulants. Renal or hepatic impairment. Ensure adequate hydration & urinary output esp w/ parenteral therapy or high doses. Monitor prothrombin time or INR in patients maintained on acenocoumarol or warfarin. Pregnancy. 228 mg/5 mL susp: Phenylketonuria. Childn w/ GFR <30 mL/min. Infants w/ immature renal function.